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   Instructions to the Authors

About the Journal | Aims and Scopes | Readership | Criteria for Publication | Trial Registration |  Rigorous Peer Review Submission Guidelines | Initial Submission | Article type / Competing Interests | Submission of Manuscripts | Preparation of Manuscripts | Copies of any permission(s) | Types of Manuscripts | Protection of Patients' Rights | Sending a revised manuscript | Reprints and proofs | Manuscript submission..Copyrights  Corrections and Retractions Contributors' form | 


 About the journal

Founded in January 2016, Asia Pacific Journal of Clinical Trials: Nervous System Diseases (CTNSD; ISSN: Print-2542-3932, Online-2542-3940) is a peer-reviewed, open-access international journal (www.actnjournal.com) with Quarterly print on demand compilation of issues published, with its mission focused on reporting creative clinical and translational advancements on the subject of nervous system diseases, psychiatric and psychological disorders.

 Aims and Scopes Top

The journal publishes papers on a broad range of the latest clinical findings of nervous system diseases, including brain, spinal cord, peripheral nerve, cranial nerve diseases, sympathetic and parasympathetic neuropathy, psychiatric and psychological disorders. In 2018, protocols and clinical trials focus on psychiatric disorders, such as depression, autism, obsession and schizophrenia are especially welcomed. The journal is also committed to publishing articles on general trial methodology as well as protocols, commentaries and traditional results papers - regardless of outcome or significance of findings.
CTNSD uses a rigorous and timely peer-review process that ensures the highest quality for publication. The journal ensures the accuracy, timeliness and completeness of the database’s content. CTNSD dedicated to disseminate each published article to achieve the largest display through the most influential international journal platform. 

 Readership Top

CTNSD has emerged as an important forum for the experts from the following disciplines including medicine, biostatistics, epidemiology, computer science, management science, pharmaceutical science, and bioethics.

 Criteria for Publication Top

• The study presents the novel results of primary scientific research.
• Experiments, statistics, and other analyses are performed to a high technical standard and are described in sufficient detail.
• Results reported have not been published elsewhere.
• Conclusions are presented in an appropriate fashion and are supported by the data.
• The research meets all applicable standards for the ethics of experimentation and research integrity.
• The article adheres to appropriate reporting guidelines and community standards for data availability.
• The article is presented in an intelligible fashion and is written in American English.

 Trial Registration Top

CTNSD supports initiatives to improve reporting of clinical trials. In line with ICMJE guidelines, the journal requires registration of all clinical trials that are reported in manuscripts submitted to CTNSD. Prospective registration is mandatory for any clinical trials. For clinical trials that have not been registered prospectively, CTNSD encourages retrospective registration to ensure the complete publication of all results. The journal accepts publicly accessible registration in ClinicalTrials.gov or in any registry that is a primary register of the WHO International Clinical Trials Registry Platform (ICTRP).

 Reporting Guidance Top


Requirements for ethical issues related to clinical trials 

• All studies performed involving human should be registered in clin­ical trials registry platform, such as clinicaltrials.gov, prior to participant recruitment. The registry platform and register identifier should be provided upon submission and included in the abstract of the manuscript.

• The ethics committee and the ap­proval number(s) should be stated in papers. Prospective clinical studies with no registration will not be ac­cepted by CTNSD. In addition, informed consent of study and protocol version should be indicated.

• Clinical manuscripts should be written according to the reporting guidelines at www.equator-network.org. Additionally, checklists and a flow chart should be provided upon sub­mission.

Protection of Patients' Rights to Privacy  Top

Identifying information should not be published in written descriptions, photographs, sonograms, CT scans, etc., and pedigrees unless the informa¬tion is essential for scientific purposes and the patient (or parent or guardian, wherever applicable) gives informed consent for publication. Authors should remove patients’ names from figures unless they have obtained in¬formed consent from the patients. The journal abides by ICMJE guidelines:

1. Authors, not the journals nor the pub¬lisher, need to obtain the patient con¬sent form before the publication and have the form properly archived. The consent forms are not to be uploaded with the cover letter or sent through email to editorial or publisher offices.

2. If the manuscript contains patient images that preclude anonymity, or a description that has obvious indi¬cation to the identity of the patient, a statement about obtaining informed patient consent should be indicated in the manuscript.

 Rigorous Peer Review   Top

Referees of CTNSD are asked to evaluate the manuscript of technically sound. Judgments about the significance of any particular paper are made after publication by the readership, who are the most qualified to determine what is of interest to them.

Editorial Process
Each submission to CTNSD passes through a quality control check and peer-review evaluation process before receiving a decision. The initial in-house quality control check deals with issues such as plagiarism check, competing interests, ethical requirements for studies involving human participants or animals, financial disclosures, full compliance with CTNSD’s data availability policy etc. Submissions may be returned to authors for queries, and will not be assigned to our Editorial Board or peer reviewers until they pass the quality control check.

Peer Review Process
Once the manuscript has passed quality control check, it is assigned to the strict double-blinded peer review process for a decision, either to accept, revise, or reject the article. Before manuscripts are sent for review, invited peer reviewers are confirmed regarding their availability, conflicts of interest with the manuscript, their agreements to have their names and comments published afterwords. A peer review report together with the reviewer’s name, if permitted, will be posted at the end of the article. Only 15–20% of over 2,000 manuscripts submitted per year are published in CTNSD. Most manuscripts will be evaluated by 3–5 external reviewers. Average time from the submission to the first editorial decision is 1 month. The review time could be shortened to 7 days for the paper with sophisticated review comments from other recognized journals in the field. According to these comments, the academic editors will make a decision as to accept, reject, request a revision or send to another peer review. 
Authors who receive a decision of Minor Revision or Major Revision have 21 days to resubmit the revised manuscript.
If you are submitting a revised manuscript, the following items with your revised submission are required:
• Response to reviewers form: Address the specific points made by each reviewer.
• Revised manuscript (traced copy): Include a traced copy of your manuscript file showing the changes you have made on the original submission.
• Revised manuscript (clean copy): Upload a clean copy of your revised manuscript that does not show your changes.
Reviewer Recognition
The quality of CTNSD depends on the effort that is generously contributed by our reviewers who have dedicated their expertise and time helping to ensure we publish great science. 
CTNSD will provide a certification of review for those who make general comments with more than 150 words and complete the peer-review process within 14 days.
We encourage the reviewers to share and discuss their review comments on Publons (www.publons.com). CTNSD will also give credit to registered reviewers on Publons.

 Open-Access Publication Top

CTNSD is co-published by Wolters Kluwer-MedKnow, a global open access medical publisher. Therefore, CTNSD applies the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License to works we publish. This license allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
Anyone interested in reading your research can get free access to your paper at our official website (www.actnjournal.com). 

 Initial Submission Top

Cover letter
Authors are required to declare the following statements, including:
• The manuscript is original, has not been submitted to or is not under consideration by another publication and has not been previously published in any language or any form, including electronic.
• All authors approve the final version of the manuscript and of its submission to CTNSD.
• Once submitted to CTNSD, the manuscript should not be submitted to other journals within 1 month, whether it is undergoing or awaiting the paper review process.

Update your ORCID record after publication
The first author or the corresponding author should provide ORCID upon manuscript submission. CTNSD also helps authors to register a unique ORCID identifier to uniquely identify author’s publication.

Transfer of copyright agreement
Once your paper is successfully submitted, publishing agreements should be signed by all authors and uploaded to the editorial system.

 Submission of Manuscripts Top

All manuscripts must be submitted on-line through the website http://www.journalonweb.com/apctnsd. First time users will have to register at this site. Registration is free but mandatory. Registered authors can keep track of their articles after logging into the site using their user name and password.

The journal does not charge for submission and processing of the manuscripts.

. If you experience any problems, please contact the editorial office by e-mail at editor [AT] actnjournal . com

The submitted manuscripts that are not as per the “Instructions to Authors” would be returned to the authors for technical correction, before they undergo editorial/ peer-review. Generally, the manuscript should be submitted in the form of two separate files:

[1] Title Page/First Page File/covering letter:

This file should provide

  1. The type of manuscript (original article, case report, review article, Letter to editor, Images, etc.) title of the manuscript, running title, names of all authors/ contributors (with their highest academic degrees, designation and affiliations) and name(s) of department(s) and/ or institution(s) to which the work should be credited, . All information which can reveal your identity should be here. Use text/rtf/doc files. Do not zip the files.
  2. The total number of pages, total number of photographs and word counts separately for abstract and for the text (excluding the references, tables and abstract), word counts for introduction + discussion in case of an original article;
  3. Source(s) of support in the form of grants, equipment, drugs, or all of these;
  4. Acknowledgement, if any. One or more statements should specify 1) contributions that need acknowledging but do not justify authorship, such as general support by a departmental chair; 2) acknowledgments of technical help; and 3) acknowledgments of financial and material support, which should specify the nature of the support. This should be included in the title page of the manuscript and not in the main article file.
  5. If the manuscript was presented as part at a meeting, the organization, place, and exact date on which it was read. A full statement to the editor about all submissions and previous reports that might be regarded as redundant publication of the same or very similar work. Any such work should be referred to specifically, and referenced in the new paper. Copies of such material should be included with the submitted paper, to help the editor decide how to handle the matter.
  6. Registration number in case of a clinical trial and where it is registered (name of the registry and its URL)
  7. Conflicts of Interest of each author/ contributor. A statement of financial or other relationships that might lead to a conflict of interest, if that information is not included in the manuscript itself or in an authors' form
  8. Criteria for inclusion in the authors’/ contributors’ list
  9. A statement that the manuscript has been read and approved by all the authors, that the requirements for authorship as stated earlier in this document have been met, and that each author believes that the manuscript represents honest work, if that information is not provided in another form (see below); and
  10. The name, address, e-mail, and telephone number of the corresponding author, who is responsible for communicating with the other authors about revisions and final approval of the proofs, if that information is not included on the manuscript itself.

[2] Blinded Article file: The main text of the article, beginning from Abstract till References (including tables) should be in this file. The file must not contain any mention of the authors' names or initials or the institution at which the study was done or acknowledgements. Page headers/running title can include the title but not the authors' names. Manuscripts not in compliance with the Journal's blinding policy will be returned to the corresponding author. Use rtf/doc files. Do not zip the files. Limit the file size to 1 MB. Do not incorporate images in the file. If file size is large, graphs can be submitted as images separately without incorporating them in the article file to reduce the size of the file. The pages should be numbered consecutively, beginning with the first page of the blinded article file.

[3] Images: Submit good quality color images. Each image should be less than 2 MB in size. Size of the image can be reduced by decreasing the actual height and width of the images (keep up to 1600 x 1200 pixels or 5-6 inches). Images can be submitted as jpeg files. Do not zip the files. Legends for the figures/images should be included at the end of the article file. 

[4] The contributors' / copyright transfer form (template provided below) has to be submitted in original with the signatures of all the contributors within two weeks of submission via courier, fax or email as a scanned image. Print ready hard copies of the images (one set) or digital images should be sent to the journal office at the time of submitting revised manuscript. High resolution images (up to 5 MB each) can be sent by email.

Contributors’ form / copyright transfer form can be submitted online from the authors’ area on http://www.journalonweb.com/apctnsd.

 Preparation of Manuscripts Top

Manuscripts must be prepared in accordance with "Uniform requirements for Manuscripts submitted to Biomedical Journals" developed by the International Committee of Medical Journal Editors (October 2008). The uniform requirements and specific requirement of Asia Pacific Journal of Clinical Trials: Nervous System Diseases are summarized below. Before submitting a manuscript, contributors are requested to check for the latest instructions available. Instructions are also available from the website of the journal (http://www.actnjournal.com) and from the manuscript submission site http://www.journalonweb.com/apctnsd).

Asia Pacific Journal of Clinical Trials: Nervous System Diseases accepts manuscripts written in American English.

-All manuscript components should be typed, double-spaced, in Arial font (10 pt). All pages should be consecutively numbered, beginning with the title page, and presented in the following order: abstract, background, protocol design, discussion, conclusion, abbreviations, competing interests, author contributions, author information, acknowledgments, figure titles, figures/tables. 
Title page
-The title should be brief (fewer than 20 words, 90 characters maximum), novel, and informative. It should identify the study type, facilitate retrieval, and be without abbreviations.
-List the names, affiliations (including department, institution, city, province/state, country, postal code), and email addresses of all authors. Specify the corresponding author.
-Maximum of 350 words. Structured with the following subheadings: Background and objectives, Design, Methods, Results /Outcome measures and preliminary results, Conclusion, Ethics and dissemination, Trial registration.

-Use as few abbreviations as possible. No citations.

Key Words
-Provide 6–10 words, representing the main content of the article.
-Original articles should cite references that have been published within the preceding 3 years. Asia Pacific Journal of Clinical Trials: Nervous System Diseases uses the reference style of The Journal of Neuroscience. Please download this style from EndNote (http://endnote.com/downloads/style/journal-neuroscience).
-References should be cited in the text as follows: “The procedure used has been described elsewhere (Green, 1978),” or “Our observations are in agreement with those of Brown and Black (1979) and of White et al. (1980),” or with multiple references, in chronological order: “Earlier reports (Brown and Black, 1979, 1981; White et al., 1980; Smith, 1982, 1984)...”.
-In the list of references (EndNote required to view download), the titles of journals should be abbreviated according to the style used in Index Medicus. The papers should be arranged in alphabetical order by the surname of the first authors. In two-author papers with the same first author, the order is alphabetical by the second author’s name. In three- or more-author papers with the same first author, the order is chronological. If there are more than 20 authors, the first 20 should be listed, followed by et al.
-The following formats are to be used:
Journal paper
       Hamill OP, Marty A, Neher E, Sakmann B, Sigworth F (1981) Improved patch-clamp techniques for high-resolution current recordings from cells and cell free membrane patches. Pflugers Arch 391:85-100.
       Hodgkin AL, Huxley AF (1952a) The components of membrane conductance in the giant axon of Loligo. J Physiol (Lond) 116:473-496.
       Hodgkin AL, Huxley AF (1952b) The dual effect of membrane potential on sodium conductance in the giant axon of Loligo. J Physiol (Lond) 116:497-506.
In-press paper
       Mollica A, Costante R, Novellino E, Stefanucci A, Pieretti S, Zador F, Samavati R, Borsodi A, Benyhe S, Vetter I, Lewis RJ (2014) Design, synthesis and biological evaluation of two opioid agonist and Cav 2.2 blocker multi-target ligands. Chem Biol Drug Des doi: 10.1111/cbdd.12479.
       Hille B (1984) Ionic channels of excitable membranes. Sunderland, MA: Sinauer.
Chapter in a book
       Stent GS (1981) Strength and weakness of the genetic approach to the development of the nervous system. In: Studies in developmental neurobiology: essays in honor of Viktor Hamburger (Cowan WM, ed), pp288-321. New York: Oxford UP.
Figures and tables
-Each figure should be provided with a fully descriptive title and legend. The area(s) of interest must be clearly indicated with arrows or other symbols.
-Figure legends must be self-explanatory and should provide sufficient detail to be intelligible without reference to the main text.
-All micrographs should contain a magnification scale bar. Please position the scale bar in the lower-right corner of a single micrograph or of the last panel (for figures with multiple panels). The length of the scale bar should be indicated on the images or in the figure legend. The images contained in a figure should be arranged in sequence from the top left to the bottom right. The tags (A, B, C…) should be positioned in the upper-left corner of each image.
-All abbreviations and labels appearing on the image should be explained in the figure legend. If the figures have been reproduced from another source, written permission for reproducing the material must be attached to the cover letter.
-The figures should be cited consecutively in the text and numbered in that order. Each figure should be placed on a separate page following the reference list and include the figure title and legend. The figure title should not be written on the figure itself. The symbols and abbreviations in the figure legends should be written out.
-All measurements in the figure should be in SI (metric) units.
-A comma should be used to separate thousands. Labels, including *, **, ***, #, ##, and ### (in that order), should be used to identify statistically significant differences between datasets on histograms or line drawings.
-Color figure: resolution > 300 dpi; file format EPS, TIFF or PDF; CMYK mode should be used rather than RGB; use high contrasting colors for color discrimination.
-Line figures: resolution > 1,200 dpi; line width between 0.5 and 4 point; file format EPS or PDF.
-Grayscale figures: resolution > 600 dpi: file format EPS, TIFF or PDF.
-Figures should remain sharp at 300-fold magnification.
-Figures should be sized to fit within a column (9 cm) or the full-text width (18 cm).
-All labels on the figures should be in Arial or Times New Roman font and be clearly legible.

 Copies of any permission(s) Top

It is the responsibility of authors/ contributors to obtain permissions for reproducing any copyrighted material. A copy of the permission obtained must accompany the manuscript. Copies of any and all published articles or other manuscripts in preparation or submitted elsewhere that are related to the manuscript must also accompany the manuscript. The material should be sent to any of the two addresses given above.

 Types of Manuscripts Top

• Study Protocol: Study protocol articles will only be considered for proposed or ongoing trials that have not completed patient recruitment at the time of submission. Please confirm the status of your study at submission. If the study has already undergone full external peer review as part of the ethics approval or funding process, the study protocol will usually only undergo editorial peer review by the handling editor. Proof of both ethics and funding will be required and we recommend that authors provide the relevant documentation on submission. Study protocols without major external funding will undergo full, external peer review. Study protocols without ethical approval will generally not be considered.
• Research Article: CTNSD will consider manuscripts on any clinical topic that is relevant to all aspects of nervous system diseases, including brain, spinal cord, peripheral nerve, and cranial nerve diseases, sympathetic and parasympathetic neuropathy, psychiatric and psychological disorders.
• Invited Reviews: Invited reviews are topical reviews, generally 6,000 words in length, which cover a current topic of interest in nervous system diseases.
• Invited perspectives: Authors with outstanding achievements in the field from international renowned laboratories are invited to write a short paper that has not been previously published, introducing their scientific hypothesis, specific animal models or patients as participants, a novel technique or method, materials, or cell type. The invited perspectives should introduce compelling new stories about how scientists or laboratories yielded their striking thoughts or achievements, rather than simply describe their research progress. These papers will provide readers with novel thoughts and insights.
• Hypotheses: Describe a hot topic in the research field of clinical trial protocols or clinical and translational medicine on nervous system diseases or psychiatric or psychological disorders. Present author’s viewpoints and the recognition and summary of this scientific process as well as future hypotheses. Highlight translational application of novel techniques and methods described in preclinical basic studies to clinical practice. 
• Methodology: Methodologies should present a new experimental or computational method, test or procedure. The method described may either be completely new, or may offer a better version of an existing method. The article must describe a demonstrable advance on what is currently available. The method needs to have been well tested and ideally, but not necessarily, used in a way that proves its value.
• Letters to the Editor: Brief communications and case reports should offer an important new observation and not simply review the literature. In rare instances, we will consider case reports for this article type, but only if the topic is extraordinarily novel.  

Each article type published by Trials follows a specific format, as detailed in the corresponding instructions for authors; please view the instructions for authors.

Manuscript Format and Structure

Study Protocol 

Title: This should include the specific study type, e.g., randomized controlled trial.
Abstract: This should be structured with the following sections. 
- Background and objectives; 
- Design 
- Methods (setting; patients’ selection, randomization, intervention)
- Outcome measures and preliminary results
- Discussion
- Ethics and dissemination (Name of Ethics Committee with Approval No., and Protocol Version)
- Trial registration (e.g., appropriate registry and the registration number and date of registration should be in stated in this section.)
Keywords: Five to ten keywords representing the main content of the article.
Strengths and limitations of this study, placed after the abstract, containing up to five short bullet points, no longer than one sentence each, that relate specifically to the methods.
Introduction: explain the rationale for the study and what evidence gap it may fill. Appropriate previous literature should be referenced, including relevant systematic reviews.
Methods and analysis: provide a full description of the study design, including the following. 
- How the sample will be selected
- Interventions to be measured
- The sample size calculation (drawing on previous literature) with an estimate of how many participants will be needed for the primary outcome to be statistically, clinically and/or politically significant
- What outcomes will be measured, when and how
- A data analysis plan.
Ethics and dissemination: ethical and safety considerations and any dissemination plan (publications, data deposition and curation) should be covered here.

Discussion (1,000 words maximum)

- Past contributions and existing problems of others in the field of research

- Discuss the major novel findings of the study and describe the different characteristics from other studies

- Disclose the limitations and bias to embody the authenticity of the contents

- Indicate the theoretical significance and practical application value of the present results and make a strong conclusion

References: use the reference style of The Journal of Neuroscience.
Figures and Tables
Additional files 

File 1: SPIRIT checklist (mandatory)
File 2: Research Organization and list of Investigators (if applicable) 
File 3: Ethical Approval (if applicable)
File 4: Informed Consent Form (if applicable)

Research Articles 

Title: 90 characters (20 words) maximum
Abstract: This should be structured with the following sections. 
- Background and objectives
- Design
- Methods
- Results
- Conclusion 
Registration details should be included in this section.
Keywords: Five to ten keywords representing the main content of the article.
Introduction (1,500 words maximum)
- Research background: 
- Novelty of this study:
- Main objective: 
Materials/Subjects and Methods 
Main findings of the study 
Discussion (1,000 words maximum)
- Past contributions and existing problems of others in the field of research
- Discuss the major novel findings of the study and describe the different characteristics from other studies 
- Disclose the limitations and bias to embody the authenticity of the contents
- Indicate the theoretical significance and practical application value of the present results and make a strong conclusion
References: 50 minimum; 30% of cited references should have been published within the preceding 3 years; use the reference style of The Journal of Neuroscience
Figures and Tables


Invited Reviews 

Word limit: 6,000 words maximum including the abstract, but excluding references, tables and figures. 
Title: 90 characters (20 words) maximum. 
Abstract: 250 words maximum, unstructured.
Keywords: Five to ten keywords representing the main content of the article. 
Body: The body should consist of a comprehensive, objective, and critical overview that is based almost exclusively on information that has been published in peer-reviewed reports. Authors are expected to present all sides of controversial issues in an even-handed manner. The review should thoroughly describe the mechanisms of injury and disease, pathophysiology, diagnosis, and treatment. Use appropriate subheadings as needed.
Conclusion: The conclusion should include a brief summary of the article and a clear indication of future research.
References: Use the reference style of The Journal of Neuroscience
Figures and Tables 

Invited Perspectives

Word limit: 2,000-3,000 words, including abstract, but excluding references, tables and figures, 3–5 published pages.  
Title: 90 characters (20 words) maximum.
Abstract: 250 words maximum, unstructured.
Keywords: Five to ten keywords representing the main content of the article. 
Body: An overview of a single theme or advanced topic for nervous system diseases, psychiatric and psychological disorders, including your opinion on particular views on a topic, the implications and applications of new technologies, the summary of your recent achievements and their applications.
References: Use the reference style of The Journal of Neuroscience
Figures and tables

The title presents a title that includes, if appropriate, the study design e.g.:
"A versus B in the treatment of C: a randomized controlled trial", "X is a risk factor for Y: a case control study", "What is the impact of factor X on subject Y: A systematic review" or for non-clinical or non-research studies a description of what the article reports
The Abstract should not exceed 350 words. Please minimize the use of abbreviations and do not cite references in the abstract. Reports of randomized controlled trials should follow the CONSORT extension for abstracts. The abstract must include the following separate sections:
- Background: the context and purpose of the study
- Methods: how the study was performed and statistical tests used
- Results: the main findings
- Conclusions: brief summary and potential implications
- Trial registration: If your article reports the results of a health care intervention on human participants, it must be registered in an appropriate registry and the registration number and date of registration should be in stated in this section. If it was not registered prospectively (before enrollment of the first participant), you should include the words 'retrospectively registered'.  
Three to ten keywords representing the main content of the article.
The Background section should explain the background to the study, its aims, a summary of the existing literature and why this study was necessary or its contribution to the field.
The methods section should include:
- The aim, design and setting of the study
- The characteristics of participants or description of materials
- A clear description of all processes, interventions and comparisons. Generic drug names should generally be used. When proprietary brands are used in research, include the brand names in parentheses
- The type of statistical analysis used, including a power calculation if appropriate.
This should include the findings of the study including, if appropriate, results of statistical analysis which must be included either in the text or as tables and figures.
This section should discuss the implications of the findings in context of existing research and highlight limitations of the study.
This should state clearly the main conclusions and provide an explanation of the importance and relevance of the study reported.
As a general rule, references should be limited to those that have a direct bearing on the understanding of the hypothesis. Use the reference style of The Journal of Neuroscience.
Figures and Tables

Abstract/ Summary
The abstract should present the paper in microcosm. It should contain explicit details of the hypothesis being advanced, the main lines of supporting evidence and the most important implications.
Five to ten keywords representing the main content of the article.
The introduction should be a concise introduction to the scientific area to be addressed, supported by appropriate references and should set the scene for the hypothesis. The introduction should not be an attempt to review the evidence in detail.
The Hypothesis/Theory
The hypothesis needs to be set out in explicit detail. Typically it should be clear why and how the hypothesis is different from current thinking, how the idea has evolved, and why it is important.
The scientific logic of the hypothesis should be clearly evident (eg. the steps in its causal assumptions).
Evaluation of the hypothesis/idea
The proposed hypothesis should be evaluated in the light of known and published information. Generally, this entails an evaluation of both evidence in support and evidence (apparently) against the hypothesis. Only relevant, and critically evaluated, papers should be cited.
An hypothesis should, if correct, have implications and make predictions. These predictions are (in principle) amenable to further observation and experimentation that could tend to confirm or refute the hypothesis. Typically, authors would be expected to indicate how their hypothesis might be tested.
Empirical data
Inclusion of extensive new data is not usually acceptable in Medical Hypotheses papers. However, at the Editor's discretion, pilot data may be included when it is required for support of the proposed hypothesis, and when it is unlikely to be published in its own right.
Consequences of the hypothesis and discussion
The importance of the hypothesis may need to be stated explicitly, with a discussion of the potential implications for the area of science under discussion if the hypothesis were to be confirmed.
As a general rule, references should be limited to those that have a direct bearing on the understanding of the hypothesis. Use the reference style of The Journal of Neuroscience.
Figures and Tables

Letters to the editor
-An in-depth analysis of an issue published in this or other journals.
-Evaluation of novel techniques, methods, and theoretical studies of concern to readers.
-Issues must meet the journal’s publishing criteria and be of interest to its readers.
-Maximum of 2,000 words, excluding references. No abstract, tables, or figures.
-Maximum of 90 characters (20 words).
Author information
-Maximum of 5. Use the reference style of The Journal of Neuroscience.


Sending a revised manuscript  Top

The revised version of the manuscript should be submitted online in a manner similar to that used for submission of the manuscript for the first time. However, there is no need to submit the “First Page” or “Covering Letter” file while submitting a revised version. When submitting a revised manuscript, contributors are requested to include, the ‘referees’ remarks along with point to point clarification at the beginning in the revised file itself. In addition, they are expected to mark the changes as underlined or colored text in the article.

Reprints and proofs  Top

Journal provides no free printed reprints. Authors can purchase reprints, payment for which should be done at the time of submitting the proofs.

Publication schedule

The journal publishes articles on its website immediately on acceptance and follows a ‘continuous publication’ schedule. Articles are compiled for ‘print on demand’ semiannual issues.

Acceptance and Publication Top

After acceptance, the authors are free inquiry regarding the progress of their manuscript online using the account number assigned to the corresponding author at any time. Generally, manuscripts will be published within 3 months after acceptance.

• Each CTNSD paper will be checked twice, using ithenticate to verify originality after submission and prior to publication. The check report will be sent to the authors.
• The similarity of any CTNSD paper should not be over 5% against one single published paper, not over 20% against all published papers.
• Similarity between new submitted manuscript and the published by the same research team or author should be not over 50%.
• No retracted articles should be cited.
• For dishonorable events including redundant (duplicate) publication, suspected plagiarism, and undisclosed conflicts of interest, CTNSD will abide by COPE guidelines (http://publicationethics.org/resources).

Publication Top

• The publisher retains all rights concerning assembling, printing, reproducing, translating, disseminating, exhibiting, publishing, retrieving and indexing part or of all the contents of the article.
• After signing transfer of copyright with the journal, the authors still retain the rights.
• In not-for-profit circumstances, the use, dissemination and reproduction of part or of all contents of the article is permitted when cited properly. 


We are committed to providing two hard copies and five high-quality reprints to authors for free. Reprints can be purchased as print or electronic reprints and as translated articles, and will be customized to your specific requirements and shrink-wrapped.


Corrections and Retractions Top

CTNSD publishes corrections, retractions, and expressions of concern as appropriate, and as quickly as possible. We follow the ICMJE and COPE guidelines where applicable.
• Correction: A notice of correction will be issued by CTNSD to correct substantial errors that appear in published articles when these errors significantly affect the content or understanding of the work (e.g., error in data presentation or analysis) or when the error affects the publication’s metadata (e.g., misspelling of an author’s name). In these cases, CTNSD will publish a correction that will be linked to the original article. In very rare cases, we may choose to correct the article itself and repost it online. If that course is taken, a correction notice will also be created to document the changes to the original article.
• Author-Initiated Retractions: CTNSD will retract an article at the authors’ request at any time unless it is under review for a possible violation of Responsible Conduct Regarding Scientific Communications. At the authors’ option, the retraction notice may simply state that the article has been retracted at the authors’ request. Alternatively, the authors may provide a brief explanation of the error(s) prompting the retraction. However, statements of retraction may not assign blame to specific authors or laboratories.
• Retractions: The editors reserve the right to retract an article at any time after publication without the consent of the authors if an investigation by an appropriate authority reveals a violation of CTNSD’s Ethics Policy.
• To request a correction/retraction, please contact the editorial office directly at apctnsd@gmail.com.

Data Availability Top

CTNSD encourages authors to upload original experimental data on journal website or Figshare prior to or after publication, including original data, images, or tables. Open access of data will increase study transparency, accelerate the scientific research pace, and establish credibility of scientific research.
Figshare is an internationally respected data repository that can upload, store, and share original data of the study. With the permission of open-access copyright, the authors can display and share their data, which facilitates retrieval, reading, download, and sharing.

Data-Sharing Statement in Clinical Trials  Top

As of 1 January 2018, manuscripts submitted to CTNSD that report the results of clinical trials must contain a data-sharing statement. We would like to bring this to your attention and the editorial office can decide whether to add any policy statement on Author Instruction page.

Contributors' form  Top

Click here to download instructions

Click here to download copyright form


These ready to use templates are made to help the contributors write as per the requirements of the Journal.

Save the templates on your computer and use them with a word processor program. 
Click open the file and save as the manuscript file.

In the program keep 'Document Map' and 'Comments' on from 'View' menu to navigate through the file. 

Download Template for Original Articles/ABSTRACT Reports. (.DOT file)

Download Template for Case Reports.  (.DOT file)

Download Template for Review Articles.  (.DOT file)

Download Template for Letter to the Editor.  (.DOT file)

Dissemination after Publication Top

Once the paper is published, it will be scheduled for dissemination via e-Newslettter.
After publication, CTNSD provides articles more visibility on the social network, e.g. Mendeley, Facebook, Twitter, LinkedIn. We also recommend authors link your paper from as many websites as possible using citation and social book marking tools such as,
• ORCID, https://orcid.org/
• ResearchGate, https://www.researchgate.net/
• Kudos, https://www.growkudos.com/
• Mendeley, https://www.mendeley.com/
• Figshare, https://figshare.com/
• DataCite, https://www.datacite.org/
• Google+, https://plus.google.com/discover
• Facebook, https://www.facebook.com/
• Twitter, https://twitter.com/
• LinkedIn, https://www.linkedin.com/
• Wikipedia http://en.wikipedia.org/wiki/Acanthamoeba_keratitis#References

Contact Us Top

Website: http://www.actnjournal.com/ 
Submission website: http://www.journalonweb.com/apctnsd 
Author inquiries: apctnsd@gmail.com
LinkedIn Account: CTNSD Zhao
Mendeley Account: Asia Pacific Journal of Clinical Trials: Nervous System Diseases
Facebook Account: CTNSD Zhao
Twitter Account: CTNSD@ctnsd_editor


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